Corneal Transplant (Graft) Rejection

What is graft rejection?

The immune system can sense that the new cornea (graft) is foreign tissue and try to destroy or 'reject' it. This happens in much the same way that the immune system fights infections. The white blood cells in the blood, lymph nodes and bone marrow are triggered to recognize the foreign tissue. These cell travel to the eye and attack the cornea. If this reaction is not stopped in time, the cornea can become cloudy and the vision becomes blurry. Fortunately, rejection reactions can almost always be stopped.

What are the symptoms? Think RSVP:

• Redness
• Sensitivity to light
• Vision loss
• Pain

What should I do if I have symptoms of a rejection?

If you have any of these symptoms for more than 12 hours or are wondering if there is a problem, please call us. We will be happy to discuss it with you and help you decide if you need to be examined.

What is the treatment for a graft rejection?

Corticosteroid eye drops are used to stop graft rejections. Also, pills and injections are sometimes used.

How successful is the treatment?

Graft rejections can almost always be stopped before the graft is seriously damaged if the medication is started promptly. Therefore, it is very important to call us and tell us about any symptoms within 24 hours. You can reach us by calling the office number (616) 949-2001. If we are not in the office, we can be paged and will call you back.