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Cornea Preservation Time Study

Verdier Eye Center, PLC , is no longer recruiting participants  for the Cornea Preservation Time Study by Case Western Reserve University.  The data is still being collected on enrolled subjects into year 2017 , however we are no longer allowing new candidates. The purpose of this study is to determine if the 3-year graft failure rate following endothelial keratoplasty performed with donor corneas with a perservation time of 8 to 14 days is non-inferior to the failure rate when donor corneas with a preservation of 7 or fewer days are used.

When the donor cornea is removed from the person who passed away, it is prepared for transplantation by an eye bank. The donor cornea is placed into a liquid that helps preserve the cornea until it is transplanted. The Food and Drug Administration (FDA) has approved storage of the cornea in this liquid for up to 14 days before the transplant. The purpose of this study is to see if the length of time the donor cornea is kept in the preservation liquid before the transplant affects the likelihood of the transplant being succesful. We will follow participants for 3 years after transplant to see if there are any differences in transplant success or in the number of transplanted endothelial cells ( the layers of cells that line the undersurface of the cornea) on the corneas that were preserved for 7 days or less compared to those preserved between 8 to 14 days. We have no reason to believe that there is any greater risk for transplant failure with either preservation time group.